When an underhanded pharmaceutical company goes to a remote tropical island to steal King Kong for advertising purposes, they get more than they bargained for when the gigantic ape attacks an unsuspecting village and an enormous octopus.

The Futurians, time-travelers from the 23rd century, arrive in Japan to warn them of the nation's destruction under Godzilla. They offer to help erase Godzilla from history by preventing his creation. With Godzilla seemingly gone, a new monster emerges as the Futurians' true intentions are revealed.

In 1933 New York, an overly ambitious movie producer coerces his cast and hired ship crew to travel to mysterious Skull Island, where they encounter Kong, a giant ape who is immediately smitten with the leading lady.

An oil company expedition disturbs the peace of a giant ape and brings him back to New York to exploit him.

After falling from the Twin Towers, Kong lies in a coma for ten years. When his heart begins to fail, scientists engineer an artificial heart, and a giant female ape is captured to serve as a source for a blood transfusion. When Kong awakens following his heart transplant, he senses the nearby presence of the female ape and the two escape to wreak havoc together.

A burning Godzilla, on the verge of meltdown, emerges to lay siege to Hong Kong. At the same time horrifying new organisms are discovered in Japan. These crustacean-like beings are seemingly born of the Oxygen Destroyer, the weapon that killed the original Godzilla.

After the previous Godzilla attack, a miniature arms race ensues to collect his cells. Concerned over Godzilla's possible return, the Japanese government uses the cells to create a new bio-weapon, ANEB (Anti-Nuclear Energy Bacteria). They seeks the aid of geneticist Genshiro Shiragami, who's experiments result in a new mutation.

Mothra's dark counterpart, Battra, emerges to eliminate humanity on behalf of the Earth. Two tiny fairies called the Cosmos offer their help by calling Mothra to battle the creature. Unfortunately a meteorite has awoken a hibernating Godzilla as a three way battle for the Earth begins.

A mysterious extraterrestrial being resembling Godzilla rapidly approaches Earth. The monster, dubbed SpaceGodzilla, lands to challenge the King of the Monsters.

Following their explosive showdown, Godzilla and Kong must reunite against a colossal undiscovered threat hidden within our world, challenging their very existence – and our own.